Non-Invasive Treatment of Extensive Eyelid Cancerous Lesion by Photodynamic Therapy: A Case Report

Cancer of the eyelid represents approximately 10% of all skin cancer in the head and neck region, and approximately 5-10% of all skin cancers. Basal cell carcinoma is the most common cutaneous malignancy in the periocular area, accounting for approximately 70-90% of all cases. The standard treatment for eyelid cancer is surgical excision with reconstruction in case of orbital invasion. Such surgery is involved and in some cases can cause irreversible functional damage to the eye, as well as significant aesthetic and emotional distress for the patient. Photodynamic therapy is a wellestablished technique for the treatment of skin basal cell carcinoma. We therefore propose photodynamic therapy as an alternative treatment of non-melanoma skin cancer and are also indicated as principal option for same types of eyelid cancer.


Non-Invasive Treatment of Extensive Eyelid Cancerous Lesion by Photodynamic
Therapy: A Case Report for preserving the vision. Therefore, it is expected that the ophthalmic, plastic and dermatological surgeons to be closely involved in such procedures.
Photodynamic therapy (PDT) is a noninvasive treatment that has shown high remission rates for several BCC's cases with excellent results when applied in the early stage of skin cancer [4]. In addition, PDT is a technically simple and noninvasive procedure that offers high level of efficacy and patient satisfaction.
Three elements are necessary in PDT: the presence of a photosensitizer (PS), which is a molecule which absorbs light to initiate a series of photochemical reactions, light at a specific wavelength to be absorbed by the PS, and the availability of molecular oxygen in the treated tissue. The combination of

Abstract
Cancer of the eyelid represents approximately 10% of all skin cancer in the head and neck region, and approximately 5-10% of all skin cancers. Basal cell carcinoma is the most common cutaneous malignancy in the periocular area, accounting for approximately 70-90% of all cases. The standard treatment for eyelid cancer is surgical excision with reconstruction in case of orbital invasion. Such surgery is involved and in some cases can cause irreversible functional damage to the eye, as well as significant aesthetic and emotional distress for the patient. Photodynamic therapy is a wellestablished technique for the treatment of skin basal cell carcinoma. We therefore propose photodynamic therapy as an alternative treatment of non-melanoma skin cancer and are also indicated as principal option for same types of eyelid cancer.
This is a case report of an eighty three year old patient with a histopathological diagnosis of basal cell carcinoma located in the left eyelid. The patient was treated by topical photodynamic therapy using a cream application of 20% Methyl-aminolevulic acid, and a fluency of 150 J/cm 2 . Clinical evaluation of the patient thirty days after treatment showed a significant clinical response with no evidence of scarring. In addition, no signs of recurrence were observed up to 6 months of follow-up. This clinical case thus showed excellent healing and cosmetic result. In summary, photodynamic therapy is a non-surgical treatment alternative that has the potential to become the number one option for eyelid cancer management, in particular for high risk patients or when surgical resection of highly involved areas is required.

Journal of Aesthetic & Reconstructive Surgery ISSN 2472-1905
compound, light and oxygen results in the production of oxidative cytotoxic agents such as singlet oxygen ( 1 O 2 ), hydroxyl radical (OH) and others, leading to necrosis, apoptosis and/or autophagy. Methyl aminolevulinate (MAL) is a pro-drug which induces the endogenous PS production and is topically administered to the patient using a transdermal delivery cream. As MAL penetrates in the cells, the aminolevulinic acid induces the production of protoporphyrin IX (PpIX) by mitochondria [5,6].
In this case report, we are presenting the treatment strategy, with the preservation of eye functions and satisfactory aesthetic results.

Case Report
An eighty-three year old female with superficial BCC with confirmed biopsy 3 cm width and 4 cm length in the eyelid region (Figure 1, panel A) was treated with topical photodynamic therapy with 20% MAL cream (PDT Pharma LTDA. Cravinhos, São Paulo, Brazil). Approval of the Ethics Committee from Amaral Carvalho Hospital (CEPFHAC n°025/11) was obtained and the patient signed a written informed consent form.
After thickness assessment, the lesion was curetted to maximize PDT treatment efficacy and the MAL cream was applied. Three hours after the MAL cream application the region was illuminated for twenty minutes with the commercial device (LINCE ® , MMOptics, Sao Paulo, Brazil) emitting light at 630 nm and intensity of 125 mW/cm 2 .
Seven days after, a second PDT procedure was performed following the clinical protocol standardized. The patient returned one month after the second session and the clinical cure as well as cosmetic satisfaction assessment of the treated area was obtained. The process was documented by photographs of the treated area using a Sony Digital Camera HSC50.

Discussion
In this clinical case, a BCC lesion involved the left medial canthus with epithelial invasion into nasal bridge (Figure 1, panel A).
The classification of tumor was confirmed by histopathological analysis.
The eyelid preserves the eye against pollutants, keeps the cornea moist [7], and its function is essential for maintaining the eye healthy and vision [8]. The periorbital skin, which protects the eyes, is one of the thinnest cutaneous surfaces of the body, with only 0.6 mm thickness [9]. The accepted standard treatment for eyelid cancer is resection surgery, which is associated with several ocular complications [10,11]. Currently, Mohs micrographic surgery is the ideal eyelid cancer removal treatment, in which a dermatologic surgeon generally works with other specialists to the success of treatment [9]. The challenges of eyelid reconstruction following the excision of the eyelid cancer are due to the anatomy and localization of the lesion. In a study performed by Souza et al. [12], the reconstruction of eyelid cancer has resulted loss of eyelid function, and a revision surgery is often required to improve eyelid structure and function [13,14].
The purpose of this report was to present a non-surgical topical treatment that is fast (two sessions, twenty minutes each) and yields excellent aesthetic results, with minimal risk of loss eye functions (Figure 1, panel C). PDT results in photochemical and photo-biological processes which cause irreversible photodamage to the treated tissues [15]. The inflammatory process occurring after seven days following the first PDT session is observed in Figure 1, panel B, which is characterized by enhanced expression of pro-inflammatory cytokines and leukocyte infiltration [16]. Many studies on the efficacy of PDT on BCC have been published [4,17,18]. However, only few studies have reported on the topical application of PDT for the treatment of BCC of eyelid cancer [19,20].
The presented clinical case showed excellent cosmetic and functional results (Figure 1, panel C), suggesting that PDT can be advantageous in cosmetically sensitive areas, such as in the face, since treatment of visible lesion can be achieved.